The main objective of formulating the dosage form is to develop a multi-unit dosage form which is basically targeted for gastro retention. This will improve the gastric residence time, which also increases the bioavailability of famotidine. It was reported that this drug absorbed only in stomach and has about 45% absolute bioavailability and undergoes degradation in colon, floating dosage form helps in better absorption of drug by releasing the drug before it reaches the site of absorption and prevents the degradation of famotidine in colon. In the present study, an attempt was made to prepare oil entrapped floating beads of famotidine prepared by inotropic gelation method using Sodium alginate, Pectin, HPMC K4M with Calcium Chloride as curing agent and various concentration of mineral oil as a floating agent. In the preliminary trials, beads were prepared without oil and various parameters were optimized such as concentration of polymer, height and size of needle, speed and time of curing agent. It was concluded that the beads with the 30% of oil ratio showed oil leakage. Beads were unable to formulate if pectin or HPMC K4M were used alone, and of irregular shape when pectin and HPMC were used. Uniform beads were formulated only with sodium alginate alone or together with pectin and HPMC K4M.
Loading....